Midbrain iron content in early Parkinson disease : A potential biomarker of disease status
Identifieur interne : 002393 ( Main/Exploration ); précédent : 002392; suivant : 002394Midbrain iron content in early Parkinson disease : A potential biomarker of disease status
Auteurs : W. R. Wayne Martin [Canada] ; Marguerite Wieler [Canada] ; Myrlene Gee [Canada]Source :
- Neurology [ 0028-3878 ] ; 2008.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Fer.
English descriptors
- KwdEn :
Abstract
Background: Parkinson disease (PD) is a progressive neurodegenerative disorder in which the major pathologic substrate is a loss of dopaminergic neurons from the lateral substantia nigra pars compacta (SNc). Our objective was to determine whether, in patients with early PD, SNc changes evident on MRI sequences sensitive to iron content corresponded anatomically to the pathologic changes reported previously, and to correlate these changes to the duration and severity of clinical manifestations of PD. Methods: Twenty-six untreated patients with early PD and 13 age- and gender-matched control subjects had MRI with a 3 tesla magnet using a multiple gradient echo sequence designed for rapid single-scan mapping of the proton transverse relaxation rate (R2*). R2* was calculated for midbrain and forebrain basal ganglia regions. Clinical features were rated with the Unified Parkinson's Disease Rating Scale. Results: A difference in measured R2* values between patients and controls was observed in the lateral SNc (p < 0.005). Linear regression indicated a correlation between the lateralized motor score from the clinically most affected side and R2* values from the opposite lateral SNc (p = 0.01). Conclusions: High field strength MRI demonstrates lateral substantia nigra pars compacta abnormalities in early Parkinson disease (PD) consistent with increased iron content and corresponding to the known distribution of neuronal loss occurring in this disorder. This may ultimately provide an imaging marker for disease progression in PD, although longitudinal studies are required.
Affiliations:
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Le document en format XML
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Wayne Martin</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Neurology, University of Alberta</s1><s2>Edmonton</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Edmonton</wicri:noRegion></affiliation></author><author><name sortKey="Wieler, Marguerite" sort="Wieler, Marguerite" uniqKey="Wieler M" first="Marguerite" last="Wieler">Marguerite Wieler</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Neurology, University of Alberta</s1><s2>Edmonton</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Edmonton</wicri:noRegion></affiliation></author><author><name sortKey="Gee, Myrlene" sort="Gee, Myrlene" uniqKey="Gee M" first="Myrlene" last="Gee">Myrlene Gee</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Biomedical Engineering, University of Alberta</s1><s2>Edmonton</s2><s3>CAN</s3><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Edmonton</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">08-0225242</idno><date when="2008">2008</date><idno type="stanalyst">PASCAL 08-0225242 INIST</idno><idno type="RBID">Pascal:08-0225242</idno><idno type="wicri:Area/PascalFrancis/Corpus">000652</idno><idno type="wicri:Area/PascalFrancis/Curation">000658</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000533</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000533</idno><idno type="wicri:doubleKey">0028-3878:2008:Martin W:midbrain:iron:content</idno><idno type="wicri:Area/Main/Merge">002594</idno><idno type="wicri:Area/Main/Curation">002393</idno><idno type="wicri:Area/Main/Exploration">002393</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Midbrain iron content in early Parkinson disease : A potential biomarker of disease status</title><author><name sortKey="Martin, W R Wayne" sort="Martin, W R Wayne" uniqKey="Martin W" first="W. R. Wayne" last="Martin">W. R. Wayne Martin</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Neurology, University of Alberta</s1><s2>Edmonton</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Edmonton</wicri:noRegion></affiliation></author><author><name sortKey="Wieler, Marguerite" sort="Wieler, Marguerite" uniqKey="Wieler M" first="Marguerite" last="Wieler">Marguerite Wieler</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Neurology, University of Alberta</s1><s2>Edmonton</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Edmonton</wicri:noRegion></affiliation></author><author><name sortKey="Gee, Myrlene" sort="Gee, Myrlene" uniqKey="Gee M" first="Myrlene" last="Gee">Myrlene Gee</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Biomedical Engineering, University of Alberta</s1><s2>Edmonton</s2><s3>CAN</s3><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Edmonton</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Iron</term><term>Midbrain</term><term>Nervous system diseases</term><term>Parkinson disease</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Mésencéphale</term><term>Fer</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Fer</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Parkinson disease (PD) is a progressive neurodegenerative disorder in which the major pathologic substrate is a loss of dopaminergic neurons from the lateral substantia nigra pars compacta (SNc). Our objective was to determine whether, in patients with early PD, SNc changes evident on MRI sequences sensitive to iron content corresponded anatomically to the pathologic changes reported previously, and to correlate these changes to the duration and severity of clinical manifestations of PD. Methods: Twenty-six untreated patients with early PD and 13 age- and gender-matched control subjects had MRI with a 3 tesla magnet using a multiple gradient echo sequence designed for rapid single-scan mapping of the proton transverse relaxation rate (R<sub>2</sub>*). R<sub>2</sub>* was calculated for midbrain and forebrain basal ganglia regions. Clinical features were rated with the Unified Parkinson's Disease Rating Scale. Results: A difference in measured R<sub>2</sub>* values between patients and controls was observed in the lateral SNc (p < 0.005). Linear regression indicated a correlation between the lateralized motor score from the clinically most affected side and R<sub>2</sub>* values from the opposite lateral SNc (p = 0.01). Conclusions: High field strength MRI demonstrates lateral substantia nigra pars compacta abnormalities in early Parkinson disease (PD) consistent with increased iron content and corresponding to the known distribution of neuronal loss occurring in this disorder. This may ultimately provide an imaging marker for disease progression in PD, although longitudinal studies are required.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Martin, W R Wayne" sort="Martin, W R Wayne" uniqKey="Martin W" first="W. R. Wayne" last="Martin">W. R. Wayne Martin</name></noRegion><name sortKey="Gee, Myrlene" sort="Gee, Myrlene" uniqKey="Gee M" first="Myrlene" last="Gee">Myrlene Gee</name><name sortKey="Wieler, Marguerite" sort="Wieler, Marguerite" uniqKey="Wieler M" first="Marguerite" last="Wieler">Marguerite Wieler</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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